NeuroQure

Revolutionizing Early Autism Risk Detection

The sooner you know, the sooner you can help

Order the Test
A woman and a young boy playing with colorful wooden building blocks on the floor
Leverage the First-of-its-Kind Autism Risk Detection Test

Leverage the First-of-its-Kind Autism Risk Detection Test

Traditional autism diagnosis often takes years. But with NeuroQure's cutting-edge ASD Insight™ test, we're changing the game. Our autism risk test for children can detect markers as early as two days after birth, allowing for potential intervention sooner. Don't wait for behavioral signs to appear - empower your child's future today with early autism risk detection.

Start Your Child's Early Detection Journey
Transform Your Practice with Early Autism Risk Detection

Transform Your Practice with Early Autism Risk Detection

As a physician, you play a crucial role in early autism risk detection. NeuroQure's ASD Insight™ autism risk screening test allows you to offer up to 80% accurate testing alongside traditional assessments. Provide families with earlier answers and pave the way for improved outcomes with autism risk testing.

Enhance Your Autism Screening Capabilities

Detecting Autism Earlier Creates the Best Chance for Successful Treatment

Since science has proven that autism is treatable through effective therapies*, the earlier treatment begins, the better the outcome for the child.

At NeuroQure, we're empowering people with children and physicians alike to transform lives. How? By receiving an accurate diagnosis of risk within days of a skin sample.

+17%IQ Improvement

The Power of Early Autism Intervention

The average age of ASD diagnosis is five years old. Early intervention leads to...

  • 41% in life-long services cost savings

  • Apply for qualifying services with traditionally long wait times

  • Plan ahead for living arrangements, schools, insurance, and more

A smiling boy gesturing with an open hand

Where Can You Get Testing for Autism Risk?

Right here at NeuroQure. Our ASD Insight™ children's autism risk test is non-invasive and provides impactful results. By detecting autism risk early, you open doors to a world of possibilities.

Early intervention autism programs can significantly improve language skills, social interactions, and cognitive development. Give your child or patients the best chance at thriving with our revolutionary early risk detection test.

Order the Test
The blue NeuroQure ASD Insight test kit box

Frequently Asked Questions

How early can you detect autism risk?
This assay's benefit is enabling the detection of ASD risk from birth, years before traditional behavioral assessments are accessible at around two years of age, through a minimally invasive specimen collection technique.
What are the benefits of early autism risk detection?
Early ASD detection improves the opportunity for early intervention, which research has demonstrated can lead to improvements in cognitive, language and social-emotional functioning in children with ASD.
Are autism risk screening tools like ASD Insight™ accurate?
To date, ASD Insight™ has not been positive in neurotypical individuals, meaning a positive result is highly associated with ASD risk. Our ASD Insight™ test has shown accuracy levels of 84% on ROC curves, similar to the ADOS test. However, to effectively eliminate false positives, the test has been calibrated with a threshold to detect 75% of cases of ASD To date, the ASD Insight™ test has not been positive in neurotypical individuals, meaning a positive result is highly associated with ASD risk.
Can improved outcomes with autism risk assessment testing like ASD Insight™ be expected?

The ASD Insight™ test can be performed at any age but may be most beneficial for birth through preschool. Limited valid diagnostic tests for autism exist for babies, and intervention during early stages of brain development in children is crucial for improving outcomes in individuals with ASD.

Early intervention is critical, and studies have shown significant behavior and IQ improvements when treatment begins early. Studies have shown that IQ can improve by 17 points when children are diagnosed at the earliest possible two years compared to those diagnosed at the typical average age of 5 years. This could make a difference for a child attending mainstream education rather than special education.

Laboratory / Test Information
  1. General information: Autism spectrum disorder (ASD) had no defined biomarkers for diagnostics or novel drug discovery. A major cluster of ASD-associated loci encode calcium signaling proteins. Functional measurement of these signals in fibroblasts shows altered intracellular Ca2+ release in monogenic syndromes associated with ASD (FMR1, TSC1, TSC2, etc.), as well as sporadic ASD. Ca2+ channels in these patients demonstrate a reduced mean open-time and therefore low flux, while other measurable parameters, such as channel abundance, selectivity, conductance, and latency, are unchanged. This result is similar to single-channel kinetic changes seen in genetic channelopathies.
  2. Methodology: The skin biopsy is processed using enzymatic dissociation and fibroblasts are cultured in standard medium. Cultured cells are plated in triplicate along with controls and then subjected to stimulation of Ca2+ signaling with ATP, ionomycin and buffer. All triplicates are averaged and normalized to a baseline based on triplicate controls included on each plate. The Ca2+ signal and closure of the calcium channel is calculated based on a previously published algorithm (Schmunk et al.) and reported as detected or not detected based on the rate of calcium flux on closure as compared to controls. The reference range is not detected based on the measured calcium flux, which is physiologic and in the range of that seen in neurotypical controls.
  3. References: Schmunk G, Nguyen RL, Ferguson DL, Kumar K, Parker I, Gargus JJ. High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder. Sci Rep. 2017;7:40740 Nguyen RL, Medvedeva YV, Ayyagari TE, Schmunk G, Gargus JJ. Intracellular calcium dysregulation in autism spectrum disorder: An analysis of converging organelle signaling pathways. Biochim Biophys Acta Mol Cell Res. 2018;1865(11 Pt B):1718-1732.Schmunk G, Boubion BJ, Smith IF, Parker I, Gargus JJ. Shared functional defect in IP3R-mediated calcium signaling in diverse monogenic autism syndromes. Transl Psychiatry. 2015;5(9):e643.
  4. Disclaimer: ASD Insight™ was developed and its performance characteristics were determined by NeuroQure, Inc, a clinical laboratory. It has not been cleared or approved by the US Food and Drug Administration. This test is used for clinical purposes. It should not be regarded as investigational or for research.
Relevant Literature
  1. Schmunk et al. 2015. Transl Psychiatry.
  2. Schmunk et al. 2017. Sci Rep.
  3. Nguyen et al. 2018. Biochim Biophys Acta Mol Cell Res.
  4. Cardenas et al. 2010. Cell.
  5. Gargus. 2009. Ann N Y Acad Sci.
  6. Filipek et al. 2004. J Autism Dev Disord.
  7. Siddiqui et al. 2023. eLife.
  8. Siddiqui et al. 2016. Autism Open Access.
  9. Makio et al. 2024. Cell Calcium.
  10. Swain et al. 2024.

*Randomized, controlled trial for toddlers with autism demonstrated average IQ improvement of 17.6 standard points, underscoring the importance of early detection of and intervention in autism. [PubMed ID: 19948568]

Take the First Step Towards Early Risk Detection

Order your ASD Insight™ early autism risk detection test today.

Order My Test