Facebook tracking pixelNeuroQure

The Science Behind NeuroQure's Test For Autism RiskUnderlined Image

patients heroSection image

The Power of Early Detection Autism Risk Testing

NeuroQure's ASD Insight autism risk screening test enables risk assessment in children as young as newborns. This is far earlier than traditional behavioral evaluations.

By identifying risk months or even years before behavioral signs emerge, patients have the potential to better manage autism spectrum disorders. In fact, early intervention leads to a formative increase in IQ, around ~10 points higher.

This makes ASD Insight an invaluable test when looking at ways to intervene sooner.

logo
test-detection-bg

The Accuracy - And Implications - Of ASD Insight

How accurate is testing for autism risk?

While not an autism prenatal testing option, the ASD Insight test can be performed just days after birth, potentially enabling early intervention autism strategies and improving autism treatment efficacy.

logo

What Does Testing For Autism Risk Show?

Our ASD Insight test detects a cellular signal shared by individuals with:

High-potency single-gene (monogenic) ASD syndromes (e.g., Fragile X, Tuberous Sclerosis)

High-throughput screen detects calcium signaling dysfunction in typical sporadic autism spectrum disorder

background Image

It's crucial to understand that the ASD Insight test:

shield

Is the risk of autism detected in NeuroQure's ASD Insight test?

shield

Can ASD Insight be used as an autism prenatal test?

shield

How does ASD Insight differ from genetic screenings for autism?

Frequently Asked Questions

Yes. ASD Insight analyzes a critical node in the complex signaling pathway leading to ASD. This node is the activation of an organellar calcium ion channel, the IP3R, found in all cells. The test measures the channel behavior as it releases the calcium store to initiate a range of cellular behaviors implicated in autism including the fusion of neurotransmitter-containing vesicles into the synapse, activation of mitochondrial ATP synthesis, immune T & B cell responses, and gut motility & secretion. The ion channel is incapable of stable opening in ASD, so all of these cellular functions are significantly impaired. A low calcium signal below a calibrated threshold is associated with ASD. In ASD Insight, signaling thresholds were set to minimize false positives. 75% of those individuals scoring in the ASD range on ADOS (Autism Diagnostic Observation Schedule) testing signal below the threshold. Specific behavioral features and severity cannot be predicted.

  1. The early autism risk detection test is recommended for use in people with an elevated risk for Autism, such as newborns from those with a previous family history, or where there is concern infants are not meeting developmental milestones. The early Autism detection test does not detect all types of Autism and should be used in addition to routine Autism screening tests recommended by a healthcare provider. The early Autism detection test is intended to detect cellular biophysical signals highly correlated with diagnosis of ASD. Use of the early Autism detection test is not recommended in individuals who are pregnant or undergoing active Autism treatment.
  2. Results should be interpreted by a healthcare provider in the context of medical history, clinical signs and symptoms. A test result of “No Autism Signal Detected” does not rule out Autism; 25% of those with ADOS-diagnosed ASD signal in the neurotypical range. The test interpretation is designed to in this fashion to minimize any false-positive results. A test result of “Autism Signal Detected” requires confirmatory medical diagnostic evaluation or by medically established procedures (e.g. ADOS) to confirm Autism.
  3. If Autism is not clinically confirmed, it could mean that the patient is still too young to manifest symptoms or that Autism is not present or testing was insufficient to detect Autism, including due to a limited skin sample. False-positive (an autism signal detected when autism is not present) and false-negative (a autism signal not detected when autism is present) test results do occur. Rx only.

dhl

Empower the Future with Cutting-Edge Science

Order your NeuroQure early detection autism risk test today.